This essay explores the theme of spirituality by comparing two radio works created on opposite sides of the Atlantic during the Second World War: The City Wears a Slouch Hat (1942) by John Cage and La Coquille à Planètes (1942–43) by Pierre Schaeffer. Although the authors belong to different aesthetic worlds, the two works have some interesting points in common. Their relationship to radio is central: both see the medium as an innovative means of expression, capable of opening up new horizons for music, but above all, of leading to a broader aesthetic and philosophical reflection, revealing a profound spirituality of a humanistic nature. The analysis of the two works reveals a dialectic between universal themes and inner dilemmas, explored with dramaturgical and expressive techniques of a surrealist matrix.